• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Die vorliegende Erfindung betrifft neue itrosoharnstoff-derivate, insbesondere N1-Glucofuranosid-6-yl-N3-nitrosoharnstoffe der allgemeinen Formel I worin R1, R2 und R5 Wasserstoff, gegebenenfalls substituiertes Alkyl oder Aralkyl oder Acyl, R1 und R2 zusammen auch Alkyliden oder Cycloalkyliden darstellen und R6 gegebenenfalls substituiertes Alkyl bedeutet und Verfahren zu deren Herstellung. Die neuen Verbindungen, zeigen eine sehr gute Wirkung bei einigen verschiedenartigen transplantablen Tumoren und Leukämien, wie auch zumTeil bei Virus-induzierter Leukämie.
    公开号:SU1028250A3
    申请号:SU792853127
    申请日:1979-12-11
    公开日:1983-07-07
    发明作者:Станек Ярослав
    申请人:Циба-Гейги Аг (Фирма)；
    IPC主号:
    专利说明:

    The invention relates to methods for producing new nitrosureas derivatives, namely, N -, - glucofyrosanosid-b-yl-Nj-nitrosoureas, which possess valuable pharmacological properties.
    The reaction of an amine with a reactive derivative of H-nitroeo-K-carbamic acid is known.
    The goal is achieved by the proposed method of obtaining derivatives of N, - glucofuranoside-b-il-K 3-nitrosomerine formula
    BUT
    H -TSH- iO-lil-llii
    zooCo
    (
    MU-ni
    . OR
    C —C2-alkyl, —COCH.; Or
    benzyl;
    H, CH-3, -COCH3, R 2 - together isopropylidene H, C., - C - alkyl, benzyl,
    -ССН ,; CH.,,
    im in that amine form,
    Bjoch
    (V
    (, ogw,
    where R, RT R. have specified ZPA. . -md, W --- - -cheni,
    subjected to interaction with the compound of the formula.,
    - (iO-i - R ", (
    "
    in a mixture of chloroform - distil ether
    The starting materials used are known or can be prepared in a known manner. Thus, an amine of formula II can be obtained from a corresponding glucofuranose not substituted in position 6, for example, by conversion into a reactive ester, for example, with an alkai or aryl-sulfonic acid or hydrohalic acid, and then by azide and reduction of the azide obtained in this way to fe-deoxy b-aminoglucofriozy.
    The methods described are carried out by known methods without or, preferably with a diluent or
    solvent, if required by cooling or; heating, under elevated pressure and / or in an inert atmosphere, for example, in a nitrogen atmosphere.
    5 Example 1 To a solution of 4.7 g of ethyl-6-amino-b-deoxy-5-O-methyl-di-B-glucofur noside in 40 ml of chloroform, cooled to a solution, is added dropwise with stirring.
    10 solution of 2.5 g of N-nitrosomethylcarbamylazide in 40 ml of ether and stirred for 3 hours at room temperature. This solution is evaporated to dryness and the residue is dissolved, distilled with 5 oh water. Extract once
    ether, the aqueous phase is separated and the lyophilization is carried out. In this way, ethyl 6 deoxy 5-0-m yl-b- (3-methyl-3-nitroeoureido) - oL-D-glu "cofuranoside, m.p. 54-55 With and
    W 65 ± 1 (chloroform, c 0.914). Yield 65% of theoretical.
    Calculated,%: C 42.80 H, 6.94; N 13.61.
    С H2;, N 0. + 0.008 Н „О
     Found; %: C 42.8; And 6.9; N 1-3,3.
    PRI mme R 2. Similarly about; the following compounds are prepared at once using the appropriate starting materials;
    a) Ethyl-6-З- (2-chloroethyl) -3-nitpbzoypeido-6-deoxi-5-0-methyl-ot-D-glu. cofuranoside, o13 ± + 53 ± 1 ° (chloroform,
    from 1.231).
    calculated,%: C 40.51, - N b, 23, N 11,81; All 9.9i5.
    .22 mHp
    Found,%: C 40.7; H 6.6; 0 N 11.3; ce 9,7
    b) Ethyl-6-deoxy-6- (3-methyl-3-nitchusouredo) - D-glucofuranoside, ti. | f + 31 i 1 set, with 1,124).
    Calculated,%: C 40.96, - H 6.53; 5 N 14.33.
    ..
    Found,%: C 41.1; H 6.4; N 14.1.
    c) 6-Deoxy-1, 2-O-isopropylidene - b- (3-methyl-3-nitrosoureido) - oi-D-glucofuranose, Cotj |, -11 + 1 ° (chloroform, c 1.002), t. square 115 ° C.
    Calculated,%: C 43.28; H 6.27, N 13.77.
    C ,, H; N o.
    Found 4: C 43.5; H 6.1; .: .. N 13.9.
    d) Ethyl 5-0-ethyl-6-deoxy-6- (3-methyl-3-nitrosoureido) - oL-P-glucofuranoside, +57 ± 0 (chloroform, c 1.023).
    Calculated,%: C, 44.86; H, 7.22; N 13.08.
    Found,%: C 45.1, - H 7.6;
    5 N 12.7. e) Ethyl-6-deoxy-6- (3-methyl-3-nitrosoyrio) -5-0-propyl-ei cofuranosyd., +1 (chloroform, c 1.045). Calculated,%: C 46.56; H 7.52; N 12.53. Found,%: C 46.6; H 7.7; N.11,8 .. e) Ethyl-5-0-benzyl-6-deoxy-6- (3-methyl-3-nitrosoureido - et-D-g cofuranoside, +41 ±. 1 (chloroform, c 1.217) Calculated,%: C 53.25; H 6.57; N 10.96., H25NzO. Found,%: C 53.1; -H 6.5; N 10.9 .. g) Methyl-6 -deoxy-6- (3-methyl-3-nitrosoureido) 5-0-methyl-dD-ch-cofuranoeid, +76 ± 1 ° (chloroform, s 1.001), t. pl. 82-83 ° C, Vnutisleno,% J e. 40,96 / N 6,53; N 14.33. -4 C pH g O-il Foundo% C 41.1; H 6.4; N 14.2. , g): Ethyl-6-rioxy: -2 5-di-0-keti-6 (3-methyl-3-nitrosoureido) - ei-D-glucofuranoside, oSZ | +97 + (chloroform, s 1.049), so pl. 93 .- Calculated,%: C 44.86; H 7.22; N 13.08. Hij-jN Oi. Found: C 45; i- H 7.1, N 13.4. . h) Ethyl 2-0-acetyl-6-deoxy-5-O-methyl-6- (3-methyl-3-nitrosourea - “C-1) -gl1ocofuranoide, foCJ. ±. (chloroform, with 1,011), so pl. 55 57C. Calculated,%: C 44.70, - H.6.64; N 12.03. SENHY., O .. Found,%: C 44.6, - H 6.9, N12, 3. - -. .fc. : and). 6-Deoxy-l, 2-di-0-acetyl-5-0-methyl-6 (3-methyl-3-nitrosoure ido) - ot-1-glucofuran6u, + li 1 (chloroform, s; 0.995) .. Calculated,%: C, 42.97; H 5.82; N 11.56. . Found,%: C 42.7; H 5.9; N 11.4. k). Benzi.l-6-deoxy-5-0-methyl-6- - (3-methyl-3-nitrosoureido) - tL-kofyranoside, Ci.J | J + 69 + 1 (chloroform, c 1.318) .. Calculated, % t C 52.02) H 6.27, N 11.37. N 0 FindT} 0,%: C52.2; H6,2; N 11.1. l) .B-Acethyl-6-deoxy-l, 2,0-isopropyliden-6- (3-methyl-3-nitrosoureido oi-B-glucofuranose, L. 3 g-26 +. 1 ° (chloroform, with 1,107 () C, 47.13; H, 6.29; N, 12.68; VC, H, N0 Found: 4: C, 47; H, 6.3, N, 12.5. Compounds of formula 1 have valuable pharmacological properties, in particular, they show a very good effect in transplanted tumors of various types and leukemia x. Thus, they cause, at doses of 25-500 mg / kg for intraperitoneal administration, strong inhibition of tumor growth in mice with Asthitis-Ehrlich carcinoma and in rats , for example with iWalker CaSa 256. Similar doses cause prod life compared with control animals in animals, such as leukemia L1210. No adverse events were found even with prolonged treatment. Even in normal animals, after three weeks of oral administration, no changes in the organs were detected. Approximate definition of DMD (maximally; , permissible dose) of compounds of formula I are given in table 1. The action with Walker-CaSa 256 in rats is presented in Table. 2.; The action against carcinoma Et i lliAscites in mice is given in table. 3.. Table 1
    Continuation of table 1
    2500 2500 2500 1250 1250 1250 2500 2500

    Dose, mg / kg animal
    Example
    1250
    1250
    1250
    500
    500
    50.0
    1250
    1250
    table 2

    Inhibition of tumor growth,%
    权利要求:
    Claims (1)
    [1]
    ¢ 54) METHOD FOR PRODUCING N 7- GLUCOFURANOSIDE — 6-IL r-Nj NITROSOMOCHEVIN of the General formula,
    BUT
    B 3 0CH where R n is C ^ -C ^ -alkyl, -COCH 3 or benzyl, * Rj-H ^ CHj, -CHCH ^, or (Chi together - isopropyl, - 4 '- den;
    R 3 - H, C .. - St-alkyl, benzyl, -COCH 3 ;
    r 4 - sn 3 , -s 2 n 4 ce, characterized in that. that the amine of General formula
    WOSO 2 where R ^ - R 3 have the indicated meanings, they are reacted with a compound of the general formula * N0 in a mixture of chloroform and diethyl ether.
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    法律状态:
    优先权:
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